Question of the Day

Theme:Neonatal jaundice

A	ABO incompatibility
B	Alpha-1-antitrypsin deficiency
C	Breast-milk
D	Crigler-Najjar syndrome
E	Cystic fibrosis
F	Galactosaemia
G	Gilbert syndrome
H	Hypothyroidism
I	Physiological
J	Rhesus disease
K	Urinary tract infection

Select the term that best matches each case.

A term 3.4 kg male infant develops jaundice within the first three days of life, which rises to 450 mmol/l, with conjugated of 25 mmol/l. He is given triple phototherapy, but at seven days of life his total bilirubin is still 380 mmol/l, still mainly unconjugated, and his stools are pale yellow. Coombs' test is negative.

Please select an optionABO incompatibilityAlpha-1-antitrypsin deficiencyBreast-milkCrigler-Najjar syndromeCystic fibrosisGalactosaemiaGilbert syndromeHypothyroidismPhysiologicalRhesus diseaseUrinary tract infection

An 8-day-old girl presents with vomiting, lethargy, poor feeding, and 4 cm hepar. The serum glucose is 0.8 mmol/l and she has a total bilirubin of 150 mmol/l, with a conjugated level of 65 mmol/l.

Please select an optionABO incompatibilityAlpha-1-antitrypsin deficiencyBreast-milkCrigler-Najjar syndromeCystic fibrosisGalactosaemiaGilbert syndromeHypothyroidismPhysiologicalRhesus diseaseUrinary tract infection

A 3.7 kg girl is born at 39 weeks' gestation and develops jaundice within the first 24 hours of life. This reaches 130 mmol/l at 12 hours of age and 200 mmol/l at 18 hours. Mother is A positive and baby B positive. The Coombs' test is weakly positive.

Please select an optionABO incompatibilityAlpha-1-antitrypsin deficiencyBreast-milkCrigler-Najjar syndromeCystic fibrosisGalactosaemiaGilbert syndromeHypothyroidismPhysiologicalRhesus diseaseUrinary tract infection